Our mitochondria-rich extracellular vesicles (MEVs) contain non-immunogenic, healthy mitochondria and bioactive proteomes. MEV-mediated mitochondrial transplantation therapy will restore the energy metabolism of the failing heart to accelerate self repair. We anticipate that this therapy will enhance the homeostatic energetics of all cells in the human body. This novel mitochondrial augmentation therapy will find effective indication for heart failure, inherited mitochondrial disease, skeletal muscle frailty, aging, stroke, diabetes, and cancer.